A secondary form of Addison's can stem from a tumor or defect in the pituitary gland, or suddenly stopping long-term steroid treatment. Addison's Disease is often caused by an autoimmune disorder which causes the dog's own immune system to view the pet's adrenal glands as a threat, then the immune system attacks and damages the adrenal glands.Īlthough it is much more rare, Addison's Disease can result from damage to your dog's adrenal glands caused by infection or trauma, or treatment for Cushing's disease. Hypoadrenocorticism or Addison's Disease in dogs is a hormonal disorder characterized by a low hormone output from your pup's adrenal glands.